cerabone® plus
NATURAL BOVINE BONE
SUBSTITUTE MATERIAL
WITH HYALURONATE
cerabone® plus
NATURAL BOVINE BONE
SUBSTITUTE MATERIAL
WITH HYALURONATE
HyA
…capable to incorporate a liquid volume 1000 times
larger than the molecule itself
Biofunctionalization
through Hyaluronic acid
Exceptional liquid binding capacity
Produced naturally in the body
Immunomodulatory activities1
Proliferation of fibroblasts2
Collagen production3
Promotes blood vessel formation and early soft tissue healing 4,5
Hyaluronic acid has been shown to enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing thus pointing to its potential indication in oral reconstructive procedures
PROF. DR. ANTON SCULEAN
1 Stern et al. (2006) Eur J Cell Biol. 85(8):699‐715.
2 Greco et al. (1998) J Cell Physiol. 177(3):465-473.
3 Rooney et al. (1993) J. Cell Sci. 105, 213–218.
4 Sattar et al. (1994) J. Invest. Dermatol. 103, 576–579.
5 King et al. (1991) Surgery. 109(1):76-84.
cerabone® plus
cerabone® plus combines the established bovine bone grafting material cerabone® with the well-known properties of hyaluronic acid.
Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® plus forms a sticky bone material upon hydration that provides unique application comfort by allowing both easy uptake and delivery to the site of application.
Application!
approx. 0.5 ml saline solution per 1.0 ml cerabone® plus
cerabone® plus requires hydration before use which can conveniently be performed in the provided blister.
Optimal consistency can be tailored to the specific needs by adjustment of liquid volume. E.g. adding slightly less liquid results in a more stable consistency, while adding more liquid enables better dispersion.
INDICATIONS
Implantology,
Periodontology,
Oral- and CMF Surgery
- Horizontal and vertical augmentation
- Peri-implant defects
- Periodontal intrabony defects
- Socket and ridge preservation
- Sinus lift
- Furcation defects (class I and II)
RECOMMENDATIONS
If the product appears dry following hydration and no connected mass has formed, additional saline solution can be added dropwise and mixed with the product until the desired texture is obtained. On the other hand, insufficient or excessive amount of liquid can result in a failure to form the described texture or a loss thereof. Likewise, excessive liquid at the augmentation site, i.e. in case of profuse bleeding in sinus floor- or socket augmentation, may reduce the handling of the bone graft during application and its adaptation to the defect. Intra-operatively, cerabone® plus performs optimally when bleeding at the defect site can be controlled, as in the case of well visible defects, e.g. in lateral augmentation.
PROPERTIES + BENEFITS
Osteoconductivity and volume stability of cerabone®
plus proven properties of hyaluronate
- Sticky and malleable following hydration
- Efficient defect filling and time-saving application
- Easy defect contouring
- Minimized displacement of single granules during application
HANDLING TIPS
- Add liquid carefully dropwise if it is not possible to measure the volume for hydration
- Remove excess liquid from the defect site prior to the application
- Preferably use in self-containing defects
- Fixate the graft with a barrier membrane
RECENT STUDIES ON HYALURONIC ACID
CLINICAL APPLICATION
CASE REPORT by Dr. Marko Blašković
Posterior mandible reconstruction using cerabone® plus, permamem® and mucoderm®
The presented case describes the rehabilitation of a challenging extended edentulous site in the posterior lower jaw, using state-of the-art bone regeneration- and soft tissue management techniques, with the goal to bring back the patient a long-term stable dentition.
