The application of hyaluronic acid in bone regeneration.

Zhai P, Peng X, Li B, Liu Y, Sun H, Li X. Int J Biol Macromol. 2020 May 15;151:1224-1239.


To review recent applications of hyaluronic acid in bone regeneration, with specific focus on potential osteopromotive effects of the biopolymer. 

Results and Conclusions:

Hyaluronic acid has been widely used in bone regeneration, particularly in the craniofacial and dental fields. Hyaluronic acid derivatives or hyaluronic acid -incorporated composite scaffolds have shown excellent potential for improving osteogenesis and mineralization. Furthermore, in order to better enhance osteogenesis, local delivery carriers based on hyaluronic acid derivatives, rather than specifically serving as scaffolds, can be established by loading different osteoinductive or osteogenetic components and acquiring different release patterns. Such osteoinductive carriers immobilized on implant surfaces are also effective in improving osseointegration. Thus, as such a competent biomaterial, hyaluronic acid should be considered a promising tool in bone regeneration.