cerabone®

Human-like bone structure
Rough, hydrophilic surface
Ultimate volume stability
1200°C maximum safety
100% pure natural bone mineral

The purest volume stable

BOVINE BONE GRAFT.

HyA

HYALURONATE

HyA

…capable to incorporate a liquid volume 1000 times
larger than the molecule itself

INTERVIEW

Dr. Devorah Schwartz-Arad about cerabone® and cerabone® plus

 

INTERVIEW

Dr. Damir Jelušić & Dr. Marko Blašković about cerabone® plus

 

Biofunctionalization
through Hyaluronic acid

Exceptional liquid binding capacity
Produced naturally in the body
Immunomodulatory activities1
Proliferation of fibroblasts2
Collagen production3 

Promotes blood vessel formation and early soft tissue healing 4,5

Hyaluronic acid has been shown to enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing thus pointing to its potential indication in oral reconstructive procedures

PROF. DR. ANTON SCULEAN

1 Stern et al. (2006) Eur J Cell Biol. 85(8):699‐715.
2 Greco et al. (1998) J Cell Physiol. 177(3):465-473.
3 Rooney et al. (1993) J. Cell Sci. 105, 213–218.
4 Sattar et al. (1994) J. Invest. Dermatol. 103, 576–579.
5 King et al. (1991) Surgery. 109(1):76-84.

cerabone® plus

cerabone® plus combines the established bovine bone grafting material cerabone® with the well-known properties of hyaluronic acid.

Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® plus forms a sticky bone material upon hydration that provides unique application comfort by allowing both easy uptake and delivery to the site of application.

STICKY BONE OUT OF THE BLISTER

State-of-the-art biotechnological fermentation processes are employed for the production of the recombinant sodium hyaluronate used in cerabone® plus.

Application!

approx. 0.5 ml saline solution per 1.0 ml cerabone® plus

cerabone® plus requires hydration before use which can conveniently be performed in the provided blister.

Optimal consistency can be tailored to the specific needs by adjustment of liquid volume. E.g. adding slightly less liquid results in a more stable consistency, while adding more liquid enables better dispersion.

INDICATIONS

Implantology,
Periodontology,
Oral- and CMF Surgery

  • Horizontal and vertical augmentation
  • Peri-implant defects
  • Periodontal intrabony defects
  • Socket and ridge preservation
  • Sinus lift
  • Furcation defects (class I and II)
RECOMMENDATIONS

If the product appears dry following hydration and no connected mass has formed, additional saline solution can be added dropwise and mixed with the product until the desired texture is obtained. On the other hand, insufficient or excessive amount of liquid can result in a failure to form the described texture or a loss thereof. Likewise, excessive liquid at the augmentation site, i.e. in case of profuse bleeding in sinus floor- or socket augmentation, may reduce the handling of the bone graft during application and its adaptation to the defect. Intra-operatively, cerabone® plus performs optimally when bleeding at the defect site can be controlled, as in the case of well visible defects, e.g. in lateral augmentation.

SPECIFICATIONS

cerabone® plus*

Art.-No. cerabone® Particle Size Content
1810** 0.5 – 1.0 mm 1 x 0.5 ml
1811 0.5 – 1.0 mm 1 x 1.0 ml
1820** 1.0 – 2.0 mm 1 x 0.5 ml
1821 1.0 – 2.0 mm 1 x 1.0 ml

* Please contact your local distributor to check for availability in your country.
** coming soon

PROPERTIES + BENEFITS

Osteoconductivity and volume stability of cerabone®
plus proven properties of hyaluronate

  • Sticky and malleable following hydration
  • Efficient defect filling and time-saving application
  • Easy defect contouring
  • Minimized displacement of single granules during application

HANDLING TIPS

  • Add liquid carefully dropwise if it is not possible to measure the volume for hydration
  • Remove excess liquid from the defect site prior to the application
  • Preferably use in self-containing defects
  • Fixate the graft with a barrier membrane

RECENT STUDIES ON HYALURONIC ACID

Hyaluronic Acid with Bone Substitutes Enhance Angiogenesis In Vivo

Solomiya Kyyak, Sebastian Blatt, Nadine Wiesmann, Ralf Smeets and Peer W. Kaemmerer
Materials 2022, 15(11), 3839

Hyaluronic Acid in Inflammation and Tissue Regeneration.

Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Wounds. 2016 Mar;28(3):78-88. 

The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro

Kyyak S, Pabst A, Heimes D, Kämmerer PW. (2021) Materials (Basel). May 27;14(11):2885.

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data.

Cervino G, Meto A, Fiorillo L, Odorici A, Meto A, D’Amico C, Oteri G, Cicciù M. Int J Environ Res Public Health. 2021 Apr 27;18(9):4670.

Hyaluronic acid: Perspectives in dentistry. A systematic review.

Casale M, Moffa A, Vella P, Sabatino L, Capuano F, Salvinelli B, Lopez MA, Carinci F, Salvinelli F. Int J Immunopathol Pharmacol. 2016 Dec;29(4):572-582.

CLINICAL APPLICATION

CASE REPORT by Dr. Tomislav Krhen

Dentigerous cyst enucleation, tooth extraction and bone augmentation with cerabone® plus – A 6-month follow-up

This case report describes the enucleation procedure of the most common type of odontogenic developmental cyst and the regeneration of the resulting bony defect using cerabone® plus.

CASE REPORT by Dr. Marko Blašković

Posterior mandible reconstruction using cerabone® plus, permamem® and mucoderm®

The presented case describes the rehabilitation of a challenging extended edentulous site in the posterior lower jaw, using state-of the-art bone regeneration- and soft tissue management techniques, with the goal to bring back the patient a long-term stable dentition.

  • WEBINAR BY:

    Prof. Anton Sculean, Dr. Marius Steigmann, Dr. Dragana Rakasevic, Dr. Miguel Stanley

    Biofunctionalization with hyaluronic acid –
    impact on dental regeneration

    In this webinar, Prof. Anton Sculean, Dr. Marius Steigmann, Dr. Dragana Rakasevic and Dr. Miguel Stanley will explain the rationale of using hyaluronic acid for tissue regeneration and will present the biological and clinical principles of the interplay of bovine bone grafting material with hyaluronic acid.

  • WEBINAR BY:

    Dr. Rafael Block Veras

    cerabone® plus for immediate implantation and sinus augmentation

    As one of the first users, Dr. Rafael Block Veras shares his clinical experience with cerabone® plus with a special focus on immediate, single tooth implants in the posterior mandible and two-stage maxillary sinus grafting. He puts particular emphasis on the advantages of the material in terms of applicability and the beneficial features in the early and late post-operative phases.

  • WEBINAR BY:

    Dr. Laszlo Parkanyi

    Bone grafting in present days – how cerabone® plus can make the difference 

    Bone substitutes as xenografts are continuously evolving to achieve more vital bone in preferably less healing time, while making handling as easy as possible.cerabone® plus is exactly this kind of material, and in this webinar, Dr. Parkanyi shows how it performs on a daily clinical basis.

  • WEBINAR BY:

    Dr. Andoni Jones

    cerabone® plus in regenerative implantology

    In this presentation Dr. Andoni Jones will be showing how cerabone® plus can be used in daily grafting procedures, from simple to complex. It's ease to use, adaptability and performance will be discussed.

  • WEBINAR BY:

    Dr. Michael R. Norton

    Insights into a new generation of biomaterials – cerabone® plus

    The video introduces a novel bovine bone mineral product cerabone® plus which utilizes hyaluronate to create outstanding handing properties which allow the particulate graft to clump in a sticky bone mass.

  • SURGERY BY:

    Dr. Devorah Schwartz-Arad

    Ridge preservation in the aesthetic zone using CTG and cerabone® plus
  • SURGERY BY:

    Dr. Filippo Fontana, Milan, Italy

    cerabone® plus for bone augmentation around an immediately placed implant
  • SURGERY BY:

    Dr. Andoni Jones, Dublin, Ireland

    Implant placement and GBR in the aesthetic zone using cerabone® plus and Jason® membrane
  • SURGERY BY:

    Dr. David Palombo

    cerabone® plus for treatment of an aesthetic implant fenestration
  • SURGERY BY:

    Dr. Massimo Frosecchi

    GBR at an implant site using cerabone® plus and mucoderm®
  • SURGERY BY:

    Dr. Stavros Pelekanos

    cerabone® plus for gap augmentation around an immediate implant
  • CLINICAL CASE BY:

    Dr. Javier Sanz Esporrin, Madrid, Spain

    REGENERATION OF AN INTRABONY DEFECT WITH CERABONE® PLUS 
  • CLINICAL CASE BY:

    Prof. Dr. Sofia Aroca, Paris, France

    Bone regeneration at two peri-implantitis affected implants using cerabone® plus and Jason® membrane
  • CLINICAL CASE BY:

    Dr. Andoni Jones, Dublin, Ireland

    CERABONE® PLUS FOR BONE AUGMENTATION AND SOFT TISSUE SUPPORT IN THE AESTHETIC ZONE
  • CLINICAL CASE BY:

    Dr. Yusuf Alshafi, London, UK

    Implant placement and bone defect augmentation in the posterior mandible
  • CLINICAL CASE BY:

    Dr. Rafael Block Veras, Berlin, Germany

    Immediate implantation in the posterior mandible
  • CLINICAL CASE BY:

    Dr. Rafael Block Veras, Berlin, Germany

    Lateral sinus floor augmentation using cerabone® plus
  • CLINICAL CASE BY:

    Dr. Stuardo Valenzuela, Coquimbo, Chile

    Immediate implant placement using cerabone® plus
  • CLINICAL CASE BY:

    Dr. László Párkányi, Szeged, Hungary

    HORIZONTAL BONE AUGMENTATION USING CERABONE® PLUS AND JASON® MEMBRANE
  • CLINICAL CASE BY:

    Dr. Michael Norton, London, UK

    CERABONE® PLUS FOR BONE AUGMENTATION OF A PERI-IMPLANTITIS-AFFECTED SITE
  • CLINICAL CASE BY:

    Dr. Serhat Aslan, Izmir, Turkey

    REGENERATION OF AN INTRABONY DEFECT WITH CERABONE® PLUS AND JASON® MEMBRANE
  • CLINICAL CASE BY:

    Dr. Damir Jelusic, Opatija, Croatia

    Extraction site management using cerabone® plus and Jason® membrane
  • CLINICAL CASE BY:

    Dr. Viktor Kalenchuk, Chernivtsi, Ukraine

    GBR at two dental implants using cerabone® plus and Jason® membrane
  • CLINICAL CASE BY:

    Dr. Viktor Kalenchuk, Chernivtsi, Ukraine

    PERI-IMPLANT BONE AUGMENTATION WITH CERABONE® PLUS AND JASON® MEMBRANE
  • CLINICAL CASE BY:

    Dr. Carlo De Annuntiis, Rome, Italy

    Hard- and soft tissue augmentation around an immediately placed implant using cerabone® plus and mucoderm®
  • CLINICAL CASE BY:

    Dr. Rafael Block Veras, Berlin, Germany

    IMMEDIATE IMPLANT PLACEMENT AND PERI-IMPLANT BONE AUGMENTATION WITH CERABONE® PLUS