cerabone® plus

NATURAL BOVINE BONE
SUBSTITUTE MATERIAL
WITH HYALURONATE

cerabone® plus

NATURAL BOVINE BONE
SUBSTITUTE MATERIAL
WITH HYALURONATE

cerabone®

Human-like bone structure
Rough, hydrophilic surface
Ultimate volume stability
1200°C maximum safety
100% pure natural bone mineral

The purest volume stable

BOVINE BONE GRAFT.

Visit 1200TRUST.com

HyA

HYALURONATE

HyA

…capable to incorporate a liquid volume 1000 times
larger than the molecule itself

Biofunctionalization
through Hyaluronic acid

Exceptional liquid binding capacity
Produced naturally in the body
Immunomodulatory activities1
Proliferation of fibroblasts2
Collagen production3 

Promotes blood vessel formation and early soft tissue healing 4,5

Hyaluronic acid has been shown to enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing thus pointing to its potential indication in oral reconstructive procedures

PROF. DR. ANTON SCULEAN

1 Stern et al. (2006) Eur J Cell Biol. 85(8):699‐715.
2 Greco et al. (1998) J Cell Physiol. 177(3):465-473.
3 Rooney et al. (1993) J. Cell Sci. 105, 213–218.
4 Sattar et al. (1994) J. Invest. Dermatol. 103, 576–579.
5 King et al. (1991) Surgery. 109(1):76-84.

Order your cerabone® plus now!

cerabone® plus

cerabone® plus combines the established bovine bone grafting material cerabone® with the well-known properties of hyaluronic acid.

Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® plus forms a sticky bone material upon hydration that provides unique application comfort by allowing both easy uptake and delivery to the site of application.

STICKY BONE OUT OF THE BLISTER

State-of-the-art biotechnological fermentation processes are employed for the production of the recombinant sodium hyaluronate used in cerabone® plus.

DOWNLOAD FAQ

Application!

approx. 0.5 ml saline solution per 1.0 ml cerabone® plus

cerabone® plus requires hydration before use which can conveniently be performed in the provided blister.

Optimal consistency can be tailored to the specific needs by adjustment of liquid volume. E.g. adding slightly less liquid results in a more stable consistency, while adding more liquid enables better dispersion.

INDICATIONS

Implantology,
Periodontology,
Oral- and CMF Surgery

  • Horizontal and vertical augmentation
  • Peri-implant defects
  • Periodontal intrabony defects
  • Socket and ridge preservation
  • Sinus lift
  • Furcation defects (class I and II)
RECOMMENDATIONS

If the product appears dry following hydration and no connected mass has formed, additional saline solution can be added dropwise and mixed with the product until the desired texture is obtained. On the other hand, insufficient or excessive amount of liquid can result in a failure to form the described texture or a loss thereof. Likewise, excessive liquid at the augmentation site, i.e. in case of profuse bleeding in sinus floor- or socket augmentation, may reduce the handling of the bone graft during application and its adaptation to the defect. Intra-operatively, cerabone® plus performs optimally when bleeding at the defect site can be controlled, as in the case of well visible defects, e.g. in lateral augmentation.

SPECIFICATIONS

cerabone® plus*

Art.-No. cerabone® Particle Size Content
1810** 0.5 – 1.0 mm 1 x 0.5 ml
1811 0.5 – 1.0 mm 1 x 1.0 ml
1820** 1.0 – 2.0 mm 1 x 0.5 ml
1821 1.0 – 2.0 mm 1 x 1.0 ml

* Please contact your local distributor to check for availability in your country.
** coming soon

Get brochure as PDF
Distributor Search

PROPERTIES + BENEFITS

Osteoconductivity and volume stability of cerabone®
plus proven properties of hyaluronate

  • Sticky and malleable following hydration
  • Efficient defect filling and time-saving application
  • Easy defect contouring
  • Minimized displacement of single granules during application

HANDLING TIPS

  • Add liquid carefully dropwise if it is not possible to measure the volume for hydration
  • Remove excess liquid from the defect site prior to the application
  • Preferably use in self-containing defects
  • Fixate the graft with a barrier membrane

RECENT STUDIES ON HYALURONIC ACID

The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro

Kyyak S, Pabst A, Heimes D, Kämmerer PW. (2021) Materials (Basel). May 27;14(11):2885.

STUDY SUMMARY
Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data.

Cervino G, Meto A, Fiorillo L, Odorici A, Meto A, D’Amico C, Oteri G, Cicciù M. Int J Environ Res Public Health. 2021 Apr 27;18(9):4670.

STUDY SUMMARY
The application of hyaluronic acid in bone regeneration.

Zhai P, Peng X, Li B, Liu Y, Sun H, Li X. Int J Biol Macromol. 2020 May 15;151:1224-1239.

STUDY SUMMARY
Hyaluronic acid: Perspectives in dentistry. A systematic review.

Casale M, Moffa A, Vella P, Sabatino L, Capuano F, Salvinelli B, Lopez MA, Carinci F, Salvinelli F. Int J Immunopathol Pharmacol. 2016 Dec;29(4):572-582.

STUDY SUMMARY

CLINICAL CASES

  • CLINICAL CASE BY:

    Dr. Serhat Aslan, Izmir, Turkey

    REGENERATION OF AN INTRABONY DEFECT WITH CERABONE® PLUS AND JASON® MEMBRANE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Andoni Jones, Dublin, Ireland

    CERABONE® PLUS FOR BONE AUGMENTATION AND SOFT TISSUE SUPPORT IN THE AESTHETIC ZONE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Viktor Kalenchuk, Chernivtsi, Ukraine

    PERI-IMPLANT BONE AUGMENTATION WITH CERABONE® PLUS AND JASON® MEMBRANE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Laura Maestre, Valladolid, Spain

    FENESTRATION DEFECT TREATED WITH CERABONE® PLUS AND JASON® MEMBRANE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Michael Norton, London, UK

    CERABONE® PLUS FOR BONE AUGMENTATION OF A PERI-IMPLANTITIS-AFFECTED SITE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. László Párkányi, Szeged, Hungary

    HORIZONTAL BONE AUGMENTATION USING CERABONE® PLUS AND JASON® MEMBRANE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Stuardo Valenzuela, Coquimbo, Chile

    PERI-IMPLANT BONE AUGMENTATION WITH CERABONE® PLUS AND JASON® MEMBRANE
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Javier Sanz Esporrin, Madrid, Spain

    REGENERATION OF AN INTRABONY DEFECT WITH CERABONE® PLUS 
    FULL CASE
  • CLINICAL CASE BY:

    Dr. Rafael Block Veras, Berlin, Germany

    IMMEDIATE IMPLANT PLACEMENT AND PERI-IMPLANT BONE AUGMENTATION WITH CERABONE® PLUS 
    FULL CASE