Hyaluronic acid: Perspectives in dentistry. A systematic review.

Casale M, Moffa A, Vella P, Sabatino L, Capuano F, Salvinelli B, Lopez MA, Carinci F, Salvinelli F. Int J Immunopathol Pharmacol. 2016 Dec;29(4):572-582.


To systematically review the published literature about potential effects of hyaluronic acid as an adjuvant treatment for chronic inflammatory disease, in addition to its use to improve healing after common dental procedures.

Results and Conclusions:

25 relevant publications were found. Three of them dealt with gingivitis, 13 with chronic periodontitis, seven with dental surgery, including implant and sinus lift procedures, and the remaining three articles with oral ulcers. The data reviewed demonstrate that, due to its positive action on tissue repair and wound healing, topical administration of hyaluronic acid could play a role not only in postoperative dental surgery, but also in the treatment of patients affected by gingivitis and periodontitis, with a significant improvement in their quality of life.