Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data.

Cervino G, Meto A, Fiorillo L, Odorici A, Meto A, D’Amico C, Oteri G, Cicciù M. Int J Environ Res Public Health. 2021 Apr 27;18(9):4670.


To analyze various surface treatments in titanium implants, demonstrating that the topography and surface chemistry of biomaterials can correlate with the host response; also focusing on the addition of hyaluronic acid to the implant surface and assessing the biological implications during early stages of recovery.

Results and Conclusions:

Used as a coating, hyaluronic acid acts on the migration, adhesion, proliferation and differentiation of cell precursors on titanium implants by improving the connection between implant and bone. Furthermore, the improvement of the bioactivity of the implant surfaces through hyaluronic acid could therefore facilitate the positioning of the dental prosthesis precisely in the early loading phase, thus satisfying the patients’ requests. It is important to note that all the findings should be supported by further experimental studies in animals as well as humans to evaluate and confirm the use of HA in any field of dentistry.